Methadone is employed in the pain management arena to deal with severe chronic pain that hasn’t resolved through the use of different therapies. Despite the fact that it has been used in the treatment field for more than 50 years, there continues to be little evidence to support the major concerns associated with long term side effects of using the drug. The methadone isn’t going to be stored overnight. Where Can I Buy Methadone Without Prescription. Wholesale Trade. In addition, it can reduce the transmission of discomfort impulses in the body. It, like other opioids, reduces the production of testosterone in both men and women and can interfere with menstrual cycles in women when used for long periods of time. When used as prescribed and under proper supervision, it has been found to be medically safe. It generally entails the entire spectrum of opioid side effects, including the development of tolerance and physical and psychological dependence.